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A broader 2024 review by Eržen and colleagues in the International Journal of Molecular Sciences places amylin within the emerging landscape of neuroendocrine hormones being developed for "diabesity." Human pharmacology data support the central mechanism: a 2005 randomized crossover study by Chapman and colleagues in Diabetologia demonstrated that pramlintide reduced food intake and increased satiety in obese and type 2 diabetic subjects, providing direct human evidence for amylin's appetite-suppressing effect
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