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A senescence-associated secretory phenotype (SASP) is commonly observed in senescent cells resident in skeletal muscle that accumulate with age, characterized by the overexpression of pro-inflammatory mediators such as Interleukin-1β (IL-1β), IL-6, IL-8, tumor necrosis factor-α (TNF-α), and Interferon-γ (IFN-γ), thereby promoting a pro-inflammatory environment (41)
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