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In hepatocytes, p38 can either exacerbate or protect against toxin-induced cell death depending on the specific isoform (p38α, p38β, p38γ, p38δ) and the timing of activation
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Therefore, metal toxicity (e.g., Ag, Cd, Cu, Hg) increases their concentrations in order to bind metals and subsequently sequester the ligand-metal complexes [55]
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