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Unlike systemic steroids where only some of the drug reaches the lungs (and the rest is spread throughout the body), inhaled steroids go directly to the active site where they are needed

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The intrinsic net charge and isoelectric point of AOD-9604 heavily influence its solubility profile across varying pH gradients in experimental buffers, complemented by molecular docking simulations that demonstrate optimal geometric fit within the active binding pockets of targeted mammalian receptor proteins, while the inclusion of specific stabilizing amino acid substitutions successfully reduces susceptibility to oxidative damage and enzymatic cleavage during extended laboratory storage