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A 2020 review on the safety of BPC-157 in preclinical (animal) studies states that the peptide “did not show any test-related effects in the single-dose toxicity study” and that it was “well tolerated” in repeat-dose evaluations.16 Other animal studies and reviews mention that BPC-157 “has no reported toxicity” or that it was “without a lethal dose” in toxicology studies.14 17 Even the authors of a small human study on BPC-157 for interstitial cystitis note that “no one dropped out of the study, and no adverse events were reported.”18 We want to highlight that most of the relevant studies have been conducted on animals, and more human research is needed

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P eff is the predicted effective human jejunal permeability