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Jiahui and colleagues reported that a DNAJC subfamily member, T-cell activation inhibitor in mitochondria (TCAIM), provides posttranslational modification and protection to α-ketoglutarate dehydrogenase in an HSPA9-dependent manner ( HSP90, HOP, and GRP-E A separate family of molecular chaperones with multiple functions, HSP90, comprises well-known counterparts of HSP70s, often concurrent with them for protein binding (especially in the UPS) and even controversial in various pathology (Soldatov et al., 2024
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