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(J Med Chem, 2017) screened several N-methylated scaffolds and found quinoliniums the most promising, with IC₅₀ values around 1 µM

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Tabe Y, Konopleva M, Kondo Y, Contractor R, Tsao T, Konoplev S, Shi Y, Ling X, Watt JC, Tsutsumi-Ishii Y, Ohsaka A, Nagaoka I, Issa JP, Kogan SC, Andreeff M

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