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However, upon exposure to powerful pro-oxidant stimuli such as dapsone or primaquine, acute extravascular and then intravascular hemolysis can occur leading to the release of heme and free iron into the local intravascular environment 57

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Fourth line defense antioxidants The action of these ‘antioxidants’ basically involves an adaptation mechanism in which they utilize the signals required for free radicals production and reaction to prevent the formation or reaction of such free radicals