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43 Another study, which compared Caucasian and Chinese populations indicated the increased susceptibility of the former to APAP hepatotoxicity reflects the lower CYP 2E1 and 2D6 activity in the latter

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In this way, the PGE 2 -Cav1.3-PARP1 axis forms a self-reinforcing survival pathway in which inflammation promotes Ca 2+ influx, and Ca 2+ influx supports anti-apoptotic signaling, allowing ectopic cells to evade clearance and persist in hostile microenvironments ( Therefore, targeting Ca 2+ signaling, particularly Cav1.3, may represent a dual therapeutic strategy by restoring mitochondrial resilience while also normalizing uterine contractility and pain-related signaling