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reported a series of benzimidazoles covalently linked to a quinolone ring and found compound 54 (IC 50 of 0.8–30 μM) was the most potent on all cancer cell lines.185 This potency was predicted via the potential to insert into the space between the base pairs of DNA, resulting in DNA cleavage
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Although the cargos of the best-understood systems are folded proteins or protein fibers, the transient interactions with the channel should theoretically enable secretins to translocate highly diverse molecules, including non-proteinaceous ones
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