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However, the use of antimicrobials also represents an evolutionary selective pressure on microbes (Aminov, 2010), and prolonged use and/or overuse in a particular environment can lead to alterations in the presence of antimicrobial resistant strains within a microbial community (e.g., increases or decreases of resistance naturally found in the population, evolution of new resistance, etc.)

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Fatigue and tiredness are listed as common adverse reactions in the Summary of Product Characteristics (SmPC) for both semaglutide (Wegovy) and liraglutide (Saxenda) as approved by the Medicines and Healthcare products Regulatory Agency (MHRA)