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Until such trials are completed, the practical message for clinicians and patients is clear: any of the three routes can correct the blood test, but choosing between them should rest on the underlying cause of deficiency, patient preference, practical feasibility and access—supported by functional biomarkers and careful clinical assessment rather than blind faith in a serum number
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Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV, Consortium C
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