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demonstrated that EC pretreatment blocked high glucose- and LPS-induced upregulation of ICAM-1 and suppressed VCAM-1 expression in NRK-52E cells, contributing to its renoprotective and anti-inflammatory effects ( 4 Role of microbial metabolism of EC in its anti-inflammatory effects As described in previous sections, the bioavailability of EC is relatively low, with nearly half remaining unabsorbed in the small intestine and undergoing microbial metabolism in the colon to generate a series of low-molecular-weight metabolites (LMWMs) (Ozdal et al., 2016)

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Furthermore, recent studies have demonstrated that Zn supplementation provides some benefits to people with obesity (with and without diabetes) by enhancing insulin sensitivity and reducing inflammation and oxidative stress (by increasing MT expression), which leads to the attenuation of the destructive effect of obesity on the liver, heart, and kidneys [81]