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Curcumin is the main phenolic pigment extracted from turmeric (the powdery rhizome of turmeric), which inhibits the expression of GPX4 and FSP1 in lung cancer cells (Zhou et al., 2023b), disrupting GPX4 activity in glioblastoma cells ( Ferroptosis has been recognized as the pathogenic mechanism of many diseases, such as neurodegenerative diseases, ischemia-reperfusion (I/R) injury, etc
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Normally, this pathway helps regulate immune responses and cell growth, but in IC, it is often activated abnormally, leading to excessive production of inflammatory cytokines like CCL8 and VEGFD
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