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Additionally, the human GPx-1 gene is downstream of the 3′-end of the rhoH12 gene, which ends only ∼800 bp upstream of the transcriptional start site for GPx-1 and is flanked by Alu repeat sequences upstream and downstream (259)
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Due to the bacterial ancestry of mitochondria, once their components are released from compromised organelles, they can be recognized by the host immune system as DAMPs, thereby providing upstream stimulation for subsequent inflammatory responses (96)
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