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For example, in the ER, it supports oxidative protein folding (52)

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It has been reported that 15% of KT recipients developed de novo DSAs over 4 years after transplantation, and graft survival at 10 years was diminished by 40% compared to patients without de novo DSAs due to chronically active AMR ( As highlighted by the Banff criteria, DSA binding to target epitopes expressed on the vascular endothelium led to acute microvascular injury that can be characterized by endothelial cell enlargement, vacuolization, loss of fenestrations, detachment from the basement membrane, and apoptosis ( Figure 1 )