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2014年微笑曾在「穀胱甘肽(Glutathione),保肝聖品?」一文, 提及口服穀胱甘肽無效論,而事隔四年,新的研究資料卻有現事有蹊蹺。故微笑在本周整理相關更新資料,與大家談談口服穀胱甘肽的保健效益。 一、 穀胱甘肽」(Glutathione=GSH)是什麼? 穀胱甘肽(穀胱甘胺酸)又簡稱為GSH,主要是由麩胺酸、胱胺酸和甘胺酸所組成的三胜肽,分子量為307,主要功能在於細胞內生性抗氧化的防禦,包括對抗反應氧物質(reactive oxygen species, RO)。是肝臟解毒過程中,最重要的元素之一(本身是強力抗氧化劑),GSH是合成具解毒性抗氧化酵素,如穀胱甘胺酸過氧化酵素(glutathione peroxidase),一種同時含硒的抗氧化酵素,人體在面對多種毒素,如農藥、乙醯胺酚等中毒時,會促使肝臟中的GSH快速耗盡,進而快速的破壞肝細胞引發急性肝衰竭。另外穀胱甘胺酸在人體免疫功能上,扮演著極為重要的角色,體內足夠的GSH濃度,能夠提高免疫系統對抗各種疾病,尤其是接受治療中的癌症患者,GSH能夠提高人體免疫系統對抗癌細胞的能力。 簡單來說,GSH在體內扮演三個功能: 強力的抗氧化劑:它自己本身能清除自由質外,更重要的它是整個抗氧化系統的樞紐,其他的抗氧化劑如維生素C、E、硫辛酸都需要有足夠的GSH,才能中和自由基
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