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However, sodium nitrite can also react with amines and amides in gastric juices, leading to the formation of nitrosamines, potent carcinogens
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This effect was particularly noted in in vivo experimental rat models of methamphetamine-induced toxicity, where melatonin prevented endothelial damage in brain capillaries by inhibiting NADPH oxidase 2 through receptor-mediated pathways [45,46,47,48]
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