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Overall, the overload of oxidized substrates together with the oxidative damage to proteasome lead to the accumulation of abnormal proteins and to selective degeneration of neurons, which characterize the AD condition (FIGURE 10)
Palliative treatment
Size:Discovery Size (10 mL)
Allometric-scaling conventions (the body-surface-area method described in FDA guidance for first-in-human dose estimation) would convert the 20 mg/kg mouse dose to a nominal figure near 1.6 mg/kg
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