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Ruenzi et al., 2005) and in experimental rat studies (see Duzel et al., 2017), and has very safe profile (LD1 could be not achieved) (Seiwerth et al., 2018), a point recently confirmed (Xu et al., 2020)

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It is important to note, however, that in the case of medicines administered by injection, the MHRA is governed also by the foundational Medicines Act 1968 (now largely embodied in the Human Medicines Regulations 2012 )