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However, the percentage increase after exposure to the enriched environment was not significantly different between control and DG-NR1KO mice (housing: p = 0.002, F (1,26) = 12.336, genotype: p = 0.530, F (1,26) = 0.404, housing × genotype: p = 0.589, F (1,26) = 0.299, two-way ANOVA

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Laboratory and early clinical literature has explored its role in skin-related signaling, but a recent skin-permeation review emphasizes that topical delivery remains an important research question