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The peptide cannot survive first-pass GI digestion without modification, and no enteric or nanoparticle encapsulation formulation for MOTS-C has been validated in peer-reviewed literature as of this writing
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Interestingly, when combined with glutathione (GSH) or N-acetyl-L-cysteine (NAC), PQQ induces 2–5 times higher apoptosis in U937 cells
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