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That ring removes the amide hydrogen, so a proline residue cannot donate a hydrogen bond to stabilise an alpha helix, and it restricts the backbone angles the chain can adopt

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3 Alcohol and oxidative stress A proper balance between antioxidants and reactive oxygen species (ROS) is generally maintained in every cell ( 2 O 2 , O 2 - , and `OH are produced due to increased NOX4 activity ( Figure 2 illustrates the damage caused by ROS to cells ( Figure 2 Ethanol and acetaldehyde both are toxic to cells