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In effect, excessive HDL can lead to the accumulation of oxidized lipids in the retina, which is related to the development of AMD [96]
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Studies conducted in mouse models of dextran sodium sulfate (DSS)-induced intestinal inflammation have shown that deletion of the SphK1 gene resulted in a more severe disease course compared to the control group, while the severity of inflammatory changes was inversely correlated with S1P levels
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