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Bacteroides fragilis EVs, while promoting M2 polarization via Sting-Sgpl1-Sema7a signaling under certain conditions, paradoxically exacerbate vascular calcification in type 2 diabetes through stimulator of interferon response cGAMP interactor 1 (Sting)-mediated phosphorylation of myocyte enhancer factor 2D (Mef2d) and subsequent upregulation of serpin family E member 1 (Serpine1)
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The antigens can also be self-antigens
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