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Small-molecule fluorescent/chemiluminescent probes Small-molecule fluorescent/chemiluminescent probes are powerful but require disciplined controls: H 2 O 2 reporters (Amplex-type, HRP-coupled) are highly sensitive for extracellular or compartment-averaged H 2 O 2 yet pool signals from multiple sources and can be confounded by endogenous peroxidases and scavengers, so include catalase or catalase-mimetics as negative controls and state explicitly whether readouts reflect intra- versus extracellular H 2 O 2 (Zhou et al

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Secondly, we have not yet involved direct comparisons between traditional Chinese herbal medicines and other clinical drugs